Twomey Lab at Johns Hopkins University

Lab News

Dec 18

Congrats, Calli!

Calli Bonin, a star undergraduate in the lab, graduates from Hopkins! Congratulations, Calli!... Read More

Dec 15

First publication!

Our time-resolved cryo-EM platform, C-SPAM, has been published in IUCrJ! Congratulations, Alejandra and Calli! Link. ... Read More

Nov 28

How to tune neurotransmitter function

Regulatory subunits tightly control the function of glutamate receptors, which enables our brains to tune responses to the neurotransmitter glutamate.... Read More

Nov 28

Allosteric Competition and Inhibition!

Small molecule therapeutics alter the three-dimensional landscape of glutamate receptors to control neurotransmission in disease states. We outline how therapeutic... Read More

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Selected Recent Publications

Montaño-Romero, A., Bonin, C., Twomey, E.C. “C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.” IUCrJ. PMID: 38096039.

Hale, W.D., Montaño-Romero, A., Gonzalez, C.U., Jayaraman, V., Lau, A.Y., Huganir, R.L., Twomey, E.C. “Allosteric Competition and Inhibition in AMPA Receptors.” BioRxiv. PMID: 38076818. Preprint.

Hale, W.D.*, Montaño-Romero, A.*, Huganir, R.L., Twomey, E.C. “Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit γ2.” BioRxiv. PMID: 38076787. Preprint.

Lab News

Selected Recent Publications

Mechanism of AMPA Receptor Inhibition